The attraction of a wink, a nod, a discarded snapshot-such feelings permeate our lives, yet we usually dismiss them as insubstantial or meaningless. With The Logic of the Lure, John Paul Ricco argues that it is precisely such fleeting, erotic, and even perverse experiences that will help us create a truly queer notion of ethics and aesthetics, one that recasts sociality and sexuality, place and finitude in ways suggested by the anonymity and itinerant lures of cruising. Shifting our (...) attention from artworks to the work that art does, from subjectivity to becoming, and from static space to taking place, Ricco considers a variety of issues, including the work of Doug Ischar, Tom Burr, and Derek Jarman and the minor architecture of sex clubs, public restrooms, and alleyways. (shrink)

Politics and the Religious Imagination is the product of a group of interdisciplinary scholars each analyzing the connections between religious narratives and the construction of regional and global politics, combining a set of theoretical and philosophic insights with several case studies that represent varied geographies and religious customs. The past decade has seen increasing interest in the links between religion and politics, and this edited volume seeks to take religion seriously as a motivator of action. Few studies have attempted to (...) bring together the multi-disciplinary work in this burgeoning field of study and this work takes a global perspective, using a variety of contexts including East-West relations to analyze the following key themes: the constructive and destructive hermeneutics of religious stories the relevance and importance of religion as a dominant political narrative the rise of new stories among groups as agents of change the way that religious narratives help to define and constrain the Other the manipulation of religious stories for political benefit This work argues that it is insufficient to judge the relationship of religion and politics through mere institutional or quantitative lenses, and this collection proves that while this promise of the narrative part of the social imaginary has been recognized in political theory to a certain extent, its influence in the realm of empirical political science has yet to be fully considered. Combining the work of a wide range of experts, this collection will be of great interests to scholars of politics, philosophy, religious studies, and the literary influence of religion. (shrink)

A measure of ethics termed ethical behavior (EB) is postulated and tested across the moral philosophy types of managers. The findings suggest that certain managers, classified as rule deontologists, appear to rank higher on the EB scale than any other philosophy type tested.

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

_The Decision Between Us _combines an inventive reading of Jean-Luc Nancy with queer theoretical concerns to argue that while scenes of intimacy are spaces of sharing, they are also spaces of separation. John Paul Ricco shows that this tension informs our efforts to coexist ethically and politically, an experience of sharing and separation that informs any decision. Using this incongruous relation of intimate separation, Ricco goes on to propose that “decision” is as much an aesthetic as it is (...) an ethical construct, and one that is always defined in terms of our relations to loss, absence, departure, and death. Laying out this theory of “unbecoming community” in modern and contemporary art, literature, and philosophy, and calling our attention to such things as blank sheets of paper, images of unmade beds, and the spaces around bodies, _The Decision Between Us _opens in 1953, when Robert Rauschenberg famously erased a drawing by Willem de Kooning, and Roland Barthes published _Writing Degree Zero_, then moves to 1980 and the “neutral mourning” of Barthes’ _Camera Lucida_, and ends in the early 1990s with installations by Felix Gonzalez-Torres. Offering surprising new considerations of these and other seminal works of art and theory by Jean Genet, Marguerite Duras, and Catherine Breillat, _The Decision Between Us_ is a highly original and unusually imaginative exploration of the spaces between us, arousing and evoking an infinite and profound sense of sharing in scenes of passionate, erotic pleasure as well as deep loss and mourning. (shrink)

In _The Future without a Past,_ John Paul Russo goes beyond currently given reasons for the decline of the humanities and searches out its root causes in the technologization of everyday life. His main premise is that we are undergoing a transformation at the hands of technological imperatives such as rationalization, universalism, monism, and autonomy. The relation between ourselves and nature has altered to such a degree that we no longer live in a natural environment but in a (...) technological one. According to Russo, technological values have actually eroded human values instead of being “humanized” by them. What are the implications of this shift for the humanities, traditionally seen as safeguards of the human? Russo addresses this question by situating the decline of the humanities within the larger social and historical panorama. He explores how technological values have infiltrated the humanities to the point of weakening their instruction and undermining their force; at the same time, he shows how the humanities have confronted these trends and can continue to do so. Russo believes that if we understand how technology “works” and the nature of its powers, we will then know in which realms it must be accepted and where it should be resisted. Russo outlines the components of the technological system and examines their impact on the educational system. He also discusses the loss of historical memory, including the so-called loss of the self and the transformation of the library. He studies the parallels between technological and literary values in criticism and theory, concluding with an analysis of the fiction of Don DeLillo, one of the most prominent contemporary novelists. DeLillo’s exploration of technology in American life, matched by a powerful critique of it from a broadly humanistic and religious perspective, serves to summarize the themes of the book as a whole. _The Future without a Past_ will appeal to scholars and students of literary studies, intellectual and cultural history, philosophy, ethics, media studies, and American studies, as well as to general readers who are seeking deeper insights into today’s cultural debates. (shrink)

Organizational ethics programs often are created to address tensions in organizational values that have been identified through repeated clinical ethics consultation requests. Clinical ethicists possess some core competencies that are suitable for the leadership of high-quality organizational ethics programs, but they may need to develop new skills to build these programs, such as familiarity with healthcare delivery science, healthcare financing, and quality improvement methodology. To this end, we suggest that clinical ethicists build organizational ethics programs incrementally and via quality improvement (...) projects undertaken in collaboration with senior clinical leaders. Organizational ethics programs often differ from clinical ethics programs in their membership and processes, and likely will require ethicists to forge new partnerships with a wide array of organizational leaders. With attention to the ways that organizational ethics programs differ from clinical ethics programs, and investment in quality improvement methodology and formal institutional needs assessments, clinical ethics leaders can position an organizational ethics program to advocate effectively for visible and compelling alignment of leadership decision making with the values of the organization. (shrink)

"Hard task to analyze a soul. . . ." We would do well to let Wordsworth's comment guide our questioning. Have we avoided "a mystical and idle sense" of an influence? Have we lost our way tracking the "most obvious and particular thought?" Have our conclusions been "in the words of reason deeply weighed?" We might well wonder with such a supreme influence on a life that is firmly stamped by independence and originality, a source of an immense influence in (...) itself. [G. E.] Moore's philosophy provided the young [I. A.] Richards with terms and concepts for his psychological aesthetics and criticism, though Richards was not long in reacting to and passing beyond this influence. More enduring was the influence on the nature of meaning, on modes of comprehending through language analysis—more enduring and pervasive, though less traceable. Then, there is Moore's example of employing multiple hypotheses to which, in his application, Richards would give the name of complementarity. Lastly, Moore's personal influence reached deeply into the student's character, and if the influence did not initiate, it fortified and still fortifies a quest for sincerity, a Socratic quest for which we can scarcely find a "beginning." John Paul Russo is associate professor of English at Camden College, Rutgers University, the editor of I. A. Richards' Complementarities: Uncollected Essays, and the author of Alexander Pope: Tradition and Identity. (shrink)

I. A. Richards ushered the spirit of Cambridge realism into semantics and literary criticism. When he arrived as an undergraduate in 1911, Cambridge was in the midst of its finest philosophical flowering since the Puritanism and Platonism of the seventeenth century. The revolution of G. E. Moore and Bertrand Russell against Hegelian idealism had already occurred; the Age of Principia was under way. There was a reassertion of native empiricism and a new interest in philosophical psychology, and the whole discussion (...) was marked increasingly by a preoccupation with language. Richards, too, would break with the past, with the history of criticism in the previous two generations, gather psychological ideas to establish an empirical semantics and aesthetics, and center his attention on language. Although Romantic and late-Victorian values inform his theories, Richards set down an original criticism on first principles, not on tradition. Many of his books' titles show this rationalist strains: The Foundations of Aesthetics , The Meaning of Meaning , Principles of Literary Criticism , Basic Rules of Reason , and The Philosophy of Rhetoric . The originality and influence of Richards' criticism can be shown by the number of terms he put into circulation, terms which became the currency of debate for almost half a century: close reading, tone, pseudostatement, stock response, tension, equilibrium, tenor and vehicle of metaphor, emotive and referential language.John Paul Russo is a professor and chairman of the English department at the University of Miami. He is the editor of I. A. Richards' Complementarities: Uncollected Essays and the author of Alexander Pope: Tradition and Identity and an annotated bibliography of Richards' works. He is currently completing a critical biography of Richards. "A Study in Influence: The Moore-Richards Paradigm," his previous contribution to Critical Inquiry, appeared in the Summer 1979 issue. (shrink)

Catholic healthcare institutions live amidst tension between three intersecting primary values, namely, a commitment of service to the poor and vulnerable, promoting the common good for all, and financially sustainability. Within this tension, the question sometimes arises as to whether it is ever justifiable, i.e., consistent with Catholic identity, to place limits on charity care. In this article we will argue that the health reform measures of the Affordable Care Act do not eliminate this tension but actually increase the urgency (...) of addressing it. Moreover, we will conclude that the question of limiting charity care in a manner that is consistent with the obligations of Catholic identity around serving the poor and vulnerable, promoting the common good, and remaining financially sustainable is not a question of if, but of how such limits are established. Such limits, however, cannot be established in light of one overriding moral consideration or principle, but must be established in light of a multitude of principles guiding us to a holistic understanding of the interrelatedness of the moral dimensions of Catholic identity. (shrink)

Recovering Reason: Essays in Honor of Thomas L. Pangle is a collection of essays composed by students and friends of Thomas L. Pangle to honor his seminal work and outstanding guidance in the study of political philosophy. These essays examine both Socrates' and modern political philosophers' attempts to answer the question of the right life for human beings, as those attempts are introduced and elaborated in the work of thinkers from Homer and Thucydides to Nietzsche and Charles Taylor.

Ever want to be famous? They didn't. It just sorta happened. Playing for friends at a pizzeria one day - full-on, massive world tour the next. Insane to a power of ten. Then, right in the middle the madness, they crash and burn. The reality of life is - stuff happens... Now, their fans are asking - what is it going to take to get pop music's latest 'phenomenon' back together? Can it even be done? In the fast paced, high-pressure (...) world that is pop music, will their passion be enough to ensure that our five accidental superstars will find their way back to doing what they were so amazingly good at? This is a story of unimaginable gain, devastating loss, and the remarkable ability of five friends, to overcome it all... (shrink)

This essay, one of three guest columns in Common Knowledge on “Economy and Humanity,” discusses Benjamin Franklin's Autobiography in the context of modern business education. In particular, it examines Franklin's “thirteen virtues” for personal success and the reaction to them of MBA students in business ethics classes at Harvard and the University of Chicago over the past decade. Asked whether Franklin's business principles have stood the test of time, students are typically skeptical that the thirteen are suited to modern commerce, (...) regarding them instead as ethical nostrums. The essay concludes by speculating on what it means that people intent on entering the business world now perceive so sharp a distinction between the principles for success in business and the principles for leading a good life. (shrink)

What does it mean to aspire to philanthropy? How might this shape popular views about charitable purpose? By one-on-one interviews and a review of the ethics of giving in the American experience, I take a long look at how views on philanthropic giving have changed over time and how this has helped to shape, and re-shape, the ethics of giving.

The classics appear conspicuously in the pamphlet wars of the American Revolution, though in the opinion of Bernard Bailyn , their presence is “window-dressing” and their influence “superficial.” They are “ everywhere illustrative, not determinative, of thought” . Up the scale in influence comes Enlightenment rationalism, also “superficial” but only “at times”—that removes the foreigners, ancient and modern. Then, further up the scale are English common-law writers, “powerfully influential” though still insufficiently “determinative”; above them, a “major source,” New England Puritan (...) thought and culture; and finally, at the top, seventeenth-century British “heroes of liberty” and the “early eighteenth-century transmitters of this tradition,” e.g. Commonwealth men, Bishop Hoadly. Who would have thought that the bishop of Winchester weighed in the balance more heavily than Plato and Aristotle? Only once in passing does Bailyn even mention Machiavelli, to whom J. G. A. Pocock, Quentin Skinner, and Harvey C. Mansfield would grant large prominence in the development of Revolutionary thought. (shrink)

Biomedical innovation and translation are increasingly emphasizing research using “big data.” The hope is that big data methods will both speed up research and make its results more applicable to “real-world” patients and health services. While big data research has been embraced by scientists, politicians, industry, and the public, numerous ethical, organizational, and technical/methodological concerns have also been raised. With respect to technical and methodological concerns, there is a view that these will be resolved through sophisticated information technologies, predictive algorithms, (...) and data analysis techniques. While such advances will likely go some way towards resolving technical and methodological issues, we believe that the epistemological issues raised by big data research have important ethical implications and raise questions about the very possibility of big data research achieving its goals. (shrink)

Contrary to much of what has been said about the decision of the United States Supreme Court last term in Exxon Shipping Co. v. Baker, it hardly put an end to the discretion of American judges to make awards of punitive damages in cases within admiralty jurisdiction. Rather, it confirmed judicial authority to make such awards in the absence of legislative direction, rejected the view that the Clean Air Act signals any intent of Congress to foreclose them in cases in (...) which that statute is implicated, and sets for them a cap, but only for an uncommon category of cases. (shrink)

Emotion expressions convey valuable information about others’ internal states and likely behaviours. Accurately identifying expressions is critical for social interactions, but so is perceiver confidence when decoding expressions. Even if a perceiver correctly labels an expression, uncertainty may impair appropriate behavioural responses and create uncomfortable interactions. Past research has found that perceivers report greater confidence when identifying emotions displayed by cultural ingroup members, an effect attributed to greater perceptual skill and familiarity with own-culture than other-culture faces. However, the current research (...) presents novel evidence for an ingroup advantage in emotion decoding confidence across arbitrary group boundaries that hold culture constant. In two experiments using different stimulus sets participants not only labeled minimal ingroup expressions more accurately, but did so with greater confidence. These results offer novel evidence that ingroup advantages in emotion decoding confidence stem partly from social-cognitive processes. (shrink)

When Benjamin Franklin suggested that man is by nature a tool-making animal, he summed up what was for his fellow Americans the common sense of the matter. It is not, then, surprising that, when Britain's colonists in North America broke with the mother country over the issue of an unrepresentative parliament's right to tax and govern the colonies, they defended their right to the property they owned on the ground that it was in a most thorough-going sense an extension of (...) themselves: the fruits of their own labor. This understanding they learned from John Locke, who based the argument of his Two Treatises of Government on the unorthodox account of providence and of man's place within the natural world that Sir Francis Bacon had been the first to articulate. All of this helps explain why the framers of the American constitution included within it a clause giving sanction to property in ideas of practical use. (shrink)

This review essay examines the emergence of the patient narrative or “pathography” in the late eighteenth and early nineteenth century in relation to the great cultural, epistemological, and ethical transformations that enabled the formation of modern medicine. John Wiltshire’s book provides an historical overview of this complex process, as well as laying the basis for a contemporary critique of some of its key assumptions.

There has been neglect of systematic conceptual development and empirical investigation within consumer ethics. Scenarios have been a long-standing tool yet their development has been haphazard with little theory guiding their development. This research answers four questions relative to this gap: Do different scenario decision frames encourage different moral reasoning styles? Does the way in which framing effects are measured make a difference in the measurement of the relationship between moral reasoning and judgment by gender? Are true framing effects likely (...) to vary with the situation? and Are true framing effects likely to vary by gender? The conclusions reached were that (1) different scenario frames encourage both types of reasoning, but rule based moral reasoning is dominant regardless of frame, (2) accounting for formal equivalency in the measurement of true framing effects is likely to enhance the interpretation of studies in moral reasoning and judgment, (3) True framing effects are more likely to occur in situations with low to moderate perceived ethicality, and (4) true framing effects are not likely to vary by gender. Explanations as to why these results occurred are discussed. (shrink)

Experiments in Love and Death is about the depth and complexity of the ethical issues that arise in illness and medicine. In his concept of 'microethics' Paul Komesaroff provides an alternative to the abstract debates about principles and consequences that have long dominated ethical thought. He shows how ethical decisions are everywhere: in small decisions, in facial expressions, in almost inconspicuous acts of recognition and trust. Through powerful descriptions of case studies and clear and concise explanations of contemporary philosophical (...) theory the book brings discussions about ethics in medicine back to where they belong-to the level of the everyday experience where people actually live, suffer and hope. A fresh and evocative look at the changing world of ethics as it applies to health and illness, this is an important book for all those touched by illness or suffering. About the author Paul Komesaroff is a physician and philosopher at Monash University in Melbourne, Australia. His books include Objectivity, Science and Society, Troubled Bodies, Sexuality and Medicine (ed. with Philipa Rothfield and John Wiltshire) and Pathways to Reconciliation (ed. with Philipa Rothfield and Cleo Fleming). (shrink)

This volume is a collection of essays by various contributors in honor of the late Laurence Berns, Richard Hammond Elliot Tutor Emeritus at St. John's College, Annapolis. The essays address the literary, political, theological, and philosophical themes of his life's work as a scholar, teacher, and constant companion of the "great books.".

What were Shakespeare's final thoughts on history, tragedy, and comedy? Shakespeare's Last Plays focuses much needed scholarly attention on Shakespeare's "Late Romances." The work--a collection of newly commissioned essays by leading scholars of classical political philosophy and literature--offers careful textual analysis of Pericles, Prince of Tyre, Cymbeline, The Winter's Tale, The Tempest, All is True, and The Two Noble Kinsmen. The essays reveal how Shakespeare's thought in these final works compliments, challenges, fulfills, or transforms previously held conceptions of the playwright (...) and his political-philosophical views. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

For forty years, Harvey Mansfield has been worth reading. Whether plumbing the depths of MachiavelliOs Discourses or explaining what was at stake in Bill ClintonOs impeachment, MansfieldOs work in political philosophy and political science has set the standard. In Educating the Prince, twenty-one of his students, themselves distinguished scholars, try to live up to that standard. Their essays offer penetrating analyses of Machiavellianism, liberalism, and America., all of them informed by MansfieldOs own work. The volume also includes a bibliography of (...) MansfieldOs writings. (shrink)

With the rising interest in the field of trauma research, many Institutional Review Boards, policymakers, parents, and others grapple with the impact of trauma-research participation on research participants' well-being. Do individuals who participate in trauma-focused research risk experiencing lasting negative effects from participation? What are the potential benefits that may be gleaned from participation in this work? How can trauma research studies be designed ethically, minimizing the risk to participants? The following review seeks to answer these questions. This review indicates (...) that most studies in this area have found that only a minority of participants experience distress when participating in trauma-focused research. Furthermore, these negative feelings tend to dissipate quickly over time, with the majority of participants self-appraising their participation as positive, rewarding, and beneficial to society. Design characteristics that may serve to minimize participants' risk of experiencing distress are discussed, as well as implications for public policy and future research. (shrink)

To claim that Hayden White has yet to be read seriously as a philosopher of history might seem false on the face of it. But do tropes and the rest provide any epistemic rationale for differing representations of historical events found in histories? As an explanation of White’s influence on philosophy of history, such a proffered emphasis only generates a puzzle with regard to taking White seriously, and not an answer to the question of why his efforts should be worthy (...) of any philosophical attention at all. For what makes his emphasis on narrative structure and its associated tropes of philosophical relevance? What, it may well be asked, did any theory that draws its categories from a stock provided by literary criticism contribute to explicating problems with regard to the warranting of claims about knowledge, explanation, or causation that represent those concerns that philosophy typically brings to this field? Robert Doran’s anthologizing of previously uncollected pieces, ranging as they do over a literal half-century of White’s published work, offers an opportunity to identify explicitly those philosophical themes and arguments that regularly and prominently feature there. Moreover, White’s essays in this volume demonstrate a credible knowledge of and interest in mainstream analytic philosophers of his era and also reveal White as deeply influenced by or well acquainted with other important philosophers of history. White thus invites a reading of his work as philosophy, and this volume presents the opportunity for accepting it as such. (shrink)